Transcriptomic Analyses of MYCN-Regulated Genes in Anaplastic Wilms’ Tumour Cell Lines Reveals Oncogenic Pathways and Potential Therapeutic Vulnerabilities

Transcriptomic Analyses of MYCN-Regulated Genes in Anaplastic Wilms’ Tumour Cell Lines Reveals Oncogenic Pathways and Potential Therapeutic Vulnerabilities

The <i>MYCN</i> proto-oncogene is deregulated in many cancers, most notably in neuroblastoma, where <i>MYCN</i> gene amplification identifies a clinical subset with very poor prognosis. Gene expression and DNA analyses have also demonstrated overexpression of <i>MYCN<...

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Bibliographic Details
Main Authors: Marianna Szemes, Zsombor Melegh, Jacob Bellamy, Ji Hyun Park, Biyao Chen, Alexander Greenhough, Daniel Catchpoole, Karim Malik
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
Wilms’ tumour
MYCN
REST
PRMT
TOMM20
RNA-seq
Online Access:https://www.mdpi.com/2072-6694/13/4/656

Internet

https://www.mdpi.com/2072-6694/13/4/656

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