TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity

TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity

Abstract Background Mutations in the small RNA-binding protein TDP-43 lead to the formation of insoluble cytoplasmic aggregates that have been associated with the onset and progression of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder affecting homeostasis of the motor system whic...

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Bibliographic Details
Main Authors: Giulia Romano, Raffaella Klima, Fabian Feiguin
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Biology
Subjects:
Neurodegeneration
Retrotransposon
TDP-43
Motoneurons
Dicer-2
siRNA
Online Access:http://link.springer.com/article/10.1186/s12915-020-00816-1

Internet

http://link.springer.com/article/10.1186/s12915-020-00816-1

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