TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity
Abstract Background Mutations in the small RNA-binding protein TDP-43 lead to the formation of insoluble cytoplasmic aggregates that have been associated with the onset and progression of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder affecting homeostasis of the motor system whic...
| Հիմնական հեղինակներ: | , , |
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| Ձևաչափ: | Հոդված |
| Լեզու: | English |
| Հրապարակվել է: |
BMC
2020-07-01
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| Շարք: | BMC Biology |
| Խորագրեր: | |
| Առցանց հասանելիություն: | http://link.springer.com/article/10.1186/s12915-020-00816-1 |