Bruceine D inhibits HIF-1α-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/β-catenin interaction

Bruceine D inhibits HIF-1α-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/β-catenin interaction

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths, characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1α (HIF-1α) is a major regulator involved in cellular response to changes of oxygen levels, supporting the adaptation of tumor cells...

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Bibliographic Details
Main Authors: Rui Huang, Lijun Zhang, Jinmei Jin, Yudong Zhou, Hongwei Zhang, Chao Lv, Dong Lu, Ye Wu, Hong Zhang, Sanhong Liu, Hongzhuan Chen, Xin Luan, Weidong Zhang
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Hepatocellular carcinoma
Bruceine D
HIF-1α
Metabolism
ICAT
β-Catenin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521001751

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http://www.sciencedirect.com/science/article/pii/S2211383521001751

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