Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation

Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation

Abstract Brain radiation necrosis (RN) or neurocognitive disorder is a severe adverse effect that may occur after radiation therapy for malignant brain tumors or head and neck cancers. RN accompanies inflammation which causes edema or micro-bleeding, and no fundamental treatment has been developed....

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Bibliographic Details
Main Authors: Natsuko Kondo, Yoshinori Sakurai, Takushi Takata, Kuniyuki Kano, Kyo Kume, Munetoshi Maeda, Nobuhiko Takai, Shugo Suzuki, Fumihiro Eto, Kenji Kikushima, Hideki Wanibuchi, Shin-Ichi Miyatake, Takayuki Kajihara, Shoji Oda, Mitsutoshi Setou, Junken Aoki, Minoru Suzuki
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-12293-3

Internet

https://doi.org/10.1038/s41598-022-12293-3

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