The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
The mechanisms behind the antibacterial activity of the natural product carolacton are unknown. Here, the authors show that carolacton is a potent inhibitor of FolD/MTHFD enzymes (involved in folate-dependent C1 metabolism in bacteria and humans) and inhibits the growth of cancer cell lines
| Hauptverfasser: | , , , , , , , , |
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| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
Nature Portfolio
2017-11-01
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| Schriftenreihe: | Nature Communications |
| Online Zugang: | https://doi.org/10.1038/s41467-017-01671-5 |