Three new shRNA expression vectors targeting the CYP3A4 coding sequence to inhibit its expression

Three new shRNA expression vectors targeting the CYP3A4 coding sequence to inhibit its expression

RNA interference (RNAi) is useful for selective gene silencing. Cytochrome P450 3A4 (CYP3A4), which metabolizes approximately 50% of drugs in clinical use, plays an important role in drug metabolism. In this study, we aimed to develop a short hairpin RNA (shRNA) to modulate CYP3A4 expression. Three...

Full description

Bibliographic Details
Main Authors: Siyun Xu, Yongsheng Xiao, Li Li, Lushan Yu, Huidi Jiang, Aiming Yu, Su Zeng
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
RNAi
Cytochrome P450
CYP3A4
shRNA
Chemosensitivity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383514000859

Internet

http://www.sciencedirect.com/science/article/pii/S2211383514000859

Similar Items