H/ACA Small RNA Dysfunctions in Disease Reveal Key Roles for Noncoding RNA Modifications in Hematopoietic Stem Cell Differentiation

H/ACA Small RNA Dysfunctions in Disease Reveal Key Roles for Noncoding RNA Modifications in Hematopoietic Stem Cell Differentiation

Noncoding RNAs control critical cellular processes, although their contribution to disease remains largely unexplored. Dyskerin associates with hundreds of H/ACA small RNAs to generate a multitude of functionally distinct ribonucleoproteins (RNPs). The DKC1 gene, encoding dyskerin, is mutated in the...

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Bibliographic Details
Main Authors: Cristian Bellodi, Mary McMahon, Adrian Contreras, Dayle Juliano, Noam Kopmar, Tomoka Nakamura, David Maltby, Alma Burlingame, Sharon A. Savage, Akiko Shimamura, Davide Ruggero
Format: Article
Language:English
Published: Elsevier 2013-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471300212X

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http://www.sciencedirect.com/science/article/pii/S221112471300212X

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