Nicotinamide (niacin) supplement increases lipid metabolism and ROS‐induced energy disruption in triple‐negative breast cancer: potential for drug repositioning as an anti‐tumor agent

Nicotinamide (niacin) supplement increases lipid metabolism and ROS‐induced energy disruption in triple‐negative breast cancer: potential for drug repositioning as an anti‐tumor agent

Metabolic dysregulation is an important hallmark of cancer. Nicotinamide (NAM), a water‐soluble amide form of niacin (vitamin B3), is currently available as a supplement for maintaining general physiologic functions. NAM is a crucial regulator of mitochondrial metabolism and redox reactions. In this...

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Bibliographic Details
Main Authors: Minsun Jung, Kyung‐Min Lee, Yebin Im, Seung Hyeok Seok, Hyewon Chung, Da Young Kim, Dohyun Han, Cheng Hyun Lee, Eun Hye Hwang, Soo Young Park, Jiwon Koh, Bohyun Kim, Ilias P. Nikas, Hyebin Lee, Daehee Hwang, Han Suk Ryu
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:Molecular Oncology
Subjects:
metabolism
nicotinamide
organoids
proteogenomics
reactive oxygen species
triple negative breast neoplasms
Online Access:https://doi.org/10.1002/1878-0261.13209

Internet

https://doi.org/10.1002/1878-0261.13209

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