Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation

Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation

AimNumerous reports have demonstrated the key importance of macrophage-elicited metabolic inflammation in insulin resistance (IR). Our previous studies confirmed that hyperuricemia or high uric acid (HUA) treatment induced an IR state in several peripheral tissues to promote the development of type...

Full description

Bibliographic Details
Main Authors: Hairong Zhao, Jiaming Lu, Furong He, Mei Wang, Yunbo Yan, Binyang Chen, De Xie, Chenxi Xu, Qiang Wang, Weidong Liu, Wei Yu, Yuemei Xi, Linqian Yu, Tetsuya Yamamoto, Hidenori Koyama, Wei Wang, Chenggui Zhang, Jidong Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
hyperuricemia
insulin resistance of macrophage
insulin signaling
IRS2-proteasome degradation
inflammatory macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.931087/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.931087/full

Similar Items