Intra-articular injection PLGA blends sustained-release microspheres loaded with meloxicam: preparation, optimization, evaluation in vitro and in vivo

Intra-articular injection PLGA blends sustained-release microspheres loaded with meloxicam: preparation, optimization, evaluation in vitro and in vivo

Meloxicam (MLX) is a commonly used drug in the clinical treatment of osteoarthritis, but it is associated with gastrointestinal adverse reactions. Therefore, in this study, we developed a sustained-release microsphere formulation of MLX for topical administration of knee joint. The MLX-loaded PLGA m...

Full description

Bibliographic Details
Main Authors: Zheng Sun, Xuejing Gu, Teng Hao, Jiali Liu, Rongrong Gao, Yanli Li, Bin Yu, Hui Xu
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Drug Delivery
Subjects:
Meloxicam
microsphere
PLGA blends
topical administration
osteoarthritis
anti-inflammatory
Online Access:https://www.tandfonline.com/doi/10.1080/10717544.2022.2144545

Internet

https://www.tandfonline.com/doi/10.1080/10717544.2022.2144545

Similar Items