Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis

Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis

Abstract Met tyrosine kinase, a receptor for a hepatocyte growth factor (HGF), plays a critical role in tumor growth, metastasis, and drug resistance. Mitochondria are highly dynamic and undergo fission and fusion to maintain a functional mitochondrial network. Dysregulated mitochondrial dynamics ar...

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Bibliographic Details
Main Authors: Yan Yu, Xiao-Dan Peng, Xiao-Jun Qian, Kai-Ming Zhang, Xiang Huang, Yu-Hong Chen, Yun-Tian Li, Gong-Kan Feng, Hai-Liang Zhang, Xue-Lian Xu, Shun Li, Xuan Li, Jia Mai, Zhi-Ling Li, Yun Huang, Dong Yang, Li-Huan Zhou, Zhuo-Yan Zhong, Jun-Dong Li, Rong Deng, Xiao-Feng Zhu
Format: Article
Language:English
Published: Nature Publishing Group 2021-12-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00790-2

Internet

https://doi.org/10.1038/s41392-021-00790-2

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