A-910823, a squalene-based emulsion adjuvant, induces T follicular helper cells and humoral immune responses via α-tocopherol component

A-910823, a squalene-based emulsion adjuvant, induces T follicular helper cells and humoral immune responses via α-tocopherol component

BackgroundAdjuvants are chemical or biological materials that enhance the efficacy of vaccines. A-910823 is a squalene-based emulsion adjuvant used for S-268019-b, a novel vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is currently in clinical development. Publishe...

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Bibliographic Details
Main Authors: Yuya Yoshioka, Kouji Kobiyama, Tomoya Hayashi, Motoyasu Onishi, Yosuke Yanagida, Takayuki Nakagawa, Masayuki Hashimoto, Anri Nishinaka, Jun Hirose, Yoshiji Asaoka, Minako Tajiri, Atsushi Hayata, Satoru Ishida, Shinya Omoto, Morio Nagira, Ken J. Ishii
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
adjuvant
A-910823
vaccine
S-268019-b
Tfh
mouse
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1116238/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1116238/full

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