Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles

Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles

Introduction: Currently, there are no approved drugs for treating non-alcoholic steatohepatitis (NASH); however, mesenchymal stem cells (MSCs) and their small extracellular vesicles (sEVs), which possess immunomodulatory activities, are potential candidates. This study aimed to develop a mouse model...

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Bibliographic Details
Main Authors: Takayuki Watanabe, Atsunori Tsuchiya, Suguru Takeuchi, Shunsuke Nojiri, Tomoaki Yoshida, Masahiro Ogawa, Michiko Itoh, Masaaki Takamura, Takayoshi Suganami, Yoshihiro Ogawa, Shuji Terai
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Regenerative Therapy
Subjects:
Non-alcoholic steatohepatitis
Cirrhosis
Mesenchymal stem cells
Small extracellular vesicles
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320420300353

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http://www.sciencedirect.com/science/article/pii/S2352320420300353

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