Identification and Characterization of Novel Proteins from Arizona Bark Scorpion Venom That Inhibit Nav1.8, a Voltage-Gated Sodium Channel Regulator of Pain Signaling

Identification and Characterization of Novel Proteins from Arizona Bark Scorpion Venom That Inhibit Nav1.8, a Voltage-Gated Sodium Channel Regulator of Pain Signaling

The voltage-gated sodium channel Nav1.8 is linked to neuropathic and inflammatory pain, highlighting the potential to serve as a drug target. However, the biophysical mechanisms that regulate Nav1.8 activation and inactivation gating are not completely understood. Progress has been hindered by a lac...

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Bibliographic Details
Main Authors: Tarek Mohamed Abd El-Aziz, Yucheng Xiao, Jake Kline, Harold Gridley, Alyse Heaston, Klaus D. Linse, Micaiah J. Ward, Darin R. Rokyta, James D. Stockand, Theodore R. Cummins, Luca Fornelli, Ashlee H. Rowe
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Toxins
Subjects:
voltage-gated sodium channel
Nav1.8
hyperpolarization
pain signaling
scorpion venom
neurotoxin
Online Access:https://www.mdpi.com/2072-6651/13/7/501

Internet

https://www.mdpi.com/2072-6651/13/7/501

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