Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice

Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice

Abstract Pancreatic ductal adenocarcinoma (PDAC), a highly lethal disease with limited therapeutic options, may benefit from repurposing of FDA-approved drugs in preventive or interceptive strategies in high-risk populations. Previous animal studies demonstrated that the use of metformin and statins...

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Bibliographic Details
Main Authors: Yaroslav Teper, Linda Ye, Richard T. Waldron, Aurelia Lugea, Xiaoying Sun, James Sinnett-Smith, Oscar J. Hines, Stephen J. Pandol, Enrique Rozengurt, Guido Eibl
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-43498-9

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https://doi.org/10.1038/s41598-023-43498-9

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