Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice

Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice

Abstract Pancreatic ductal adenocarcinoma (PDAC), a highly lethal disease with limited therapeutic options, may benefit from repurposing of FDA-approved drugs in preventive or interceptive strategies in high-risk populations. Previous animal studies demonstrated that the use of metformin and statins...

Full description

Bibliographic Details
Main Authors:	Yaroslav Teper, Linda Ye, Richard T. Waldron, Aurelia Lugea, Xiaoying Sun, James Sinnett-Smith, Oscar J. Hines, Stephen J. Pandol, Enrique Rozengurt, Guido Eibl
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-09-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-023-43498-9

Similar Items

Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice.
by: Hui-Hua Chang, et al.
Published: (2017-01-01)

Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice
by: Mu Xu, et al.
Published: (2018-08-01)

Statins Inhibit Inflammatory Cytokine Production by Macrophages and Acinar-to-Ductal Metaplasia of Pancreatic Cells
by: Soichiro Ako, et al.
Published: (2022-01-01)

Crosstalk between KRAS, SRC and YAP Signaling in Pancreatic Cancer: Interactions Leading to Aggressive Disease and Drug Resistance
by: Enrique Rozengurt, et al.
Published: (2021-10-01)

p53 dosage can impede KrasG12D- and KrasQ61R-mediated tumorigenesis.
by: Özgün Le Roux, et al.
Published: (2024-01-01)

Pancreatic Macrophages: Critical Players in Obesity-Promoted Pancreatic Cancer
by: Yaroslav Teper, et al.
Published: (2020-07-01)

Environmental Stressors and the Unfolded Protein Response (UPR) in Exocrine Pancreatic Function
by: Stephen J Pandol, et al.
Published: (2011-03-01)

Obesity and Pancreatic Cancer: Insight into Mechanisms
by: Guido Eibl, et al.
Published: (2021-10-01)

Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells.
by: Ming Ming, et al.
Published: (2014-01-01)

Differential Cell Susceptibilities to KrasG12D in the Setting of Obstructive Chronic PancreatitisSummary
by: Chanjuan Shi, et al.
Published: (2019-01-01)

Yes-Associated Protein 1 Plays Major Roles in Pancreatic Stellate Cell Activation and Fibroinflammatory Responses
by: Cheng Hu, et al.
Published: (2019-12-01)

Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation
by: Qiang Zhang, et al.
Published: (2016-11-01)

KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells
by: Angela J. Mathison, et al.
Published: (2021-10-01)

Incidence of New Onset Diabetes Mellitus Secondary to Acute Pancreatitis: A Systematic Review and Meta-Analysis
by: Mengmeng Zhi, et al.
Published: (2019-05-01)

Constitutively Active Akt1 Cooperates with KRasG12D to Accelerate In Vivo Pancreatic Tumor Onset and Progression
by: Toya M. Albury, et al.
Published: (2015-02-01)

The Unfolded Protein Response Plays a Predominant Homeostatic Role in Response to Mitochondrial Stress in Pancreatic Stellate Cells.
by: Hsin-Yuan Su, et al.
Published: (2016-01-01)

Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors
by: Lisa Goebel, et al.
Published: (2023-03-01)

Naproxen inhibits spontaneous lung adenocarcinoma formation in KrasG12V mice
by: Gaurav Kumar, et al.
Published: (2021-06-01)

Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells.
by: Heloisa P Soares, et al.
Published: (2013-01-01)

Counteracting gemcitabine+nab-paclitaxel induced dysbiosis in KRAS wild type and KRASG12D mutated pancreatic cancer in vivo model
by: Concetta Panebianco, et al.
Published: (2023-04-01)

Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation
by: Shaima’a Hamarsheh, et al.
Published: (2020-04-01)

Inhibition of Pancreatic Intraepithelial Neoplasia Progression to Carcinoma by Nitric Oxide-Releasing Aspirin in p48Cre/+-LSL-KrasG12D/+ Mice
by: Chinthalapally V. Rao, et al.
Published: (2012-09-01)

Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways.
by: Minzhao Huang, et al.
Published: (2014-01-01)

CBX4 deletion promotes tumorigenesis under KrasG12D background by inducing genomic instability
by: Fangzhen Chen, et al.
Published: (2023-09-01)

Inactivation of Rbx1 E3 ligase suppresses KrasG12D‐driven lung tumorigenesis
by: Yanan Li, et al.
Published: (2023-08-01)

Covalent inhibitor targets KRasG12C: A new paradigm for drugging the undruggable and challenges ahead
by: Hui-yu Li, et al.
Published: (2023-03-01)

Correction: Inactivation of TIF1γ Cooperates with KrasG12D to Induce Cystic Tumors of the Pancreas
Published: (2009-08-01)

The Mouse Model of Pancreatic Cancer Atlas (MMPCA) for classification of pancreatic cancer lesions: A large histological investigation of the Ptf1aCre/+;LSL-KrasG12D/+ transgenic mouse model of pancreatic cancer.
by: Michelle J Veite-Schmahl, et al.
Published: (2017-01-01)

Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition.
by: Sharmila Shankar, et al.
Published: (2011-01-01)

Conditional knockout of N-WASP enhanced the formation of keratinizing squamous cell carcinoma induced by KRasG12D
by: Kalailingam, Pazhanichamy, et al.
Published: (2024)

Endogenous n-3 Polyunsaturated Fatty Acids Delay Progression of Pancreatic Ductal Adenocarcinoma in Fat-1-p48Cre/+-LSL-KrasG12D/+ Mice
by: Altaf Mohammed, et al.
Published: (2012-12-01)

Effect of Metformin and Simvastatin in Inhibiting Proadipogenic Transcription Factors
by: Jelena Jakab, et al.
Published: (2021-11-01)

Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic Acinar Cells Leads to Chronic PancreatitisSummary
by: Michelle M. Cooley, et al.
Published: (2021-01-01)

Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors
by: Patricia Santofimia-Castaño, et al.
Published: (2024-02-01)

High-throughput, single-particle tracking reveals nested membrane domains that dictate KRasG12D diffusion and trafficking
by: Yerim Lee, et al.
Published: (2019-11-01)

AGO2 in overexpression exhibits oncogenic functions KrasG̳1̳2̳D̳ -associated mouse tumor models
by: Thai, Kevin K. (Kevin Kinh)
Published: (2018)

Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells
by: Monica Dalva, et al.
Published: (2020-01-01)

Porcine pancreatic ductal epithelial cells transformed with KRASG12D and SV40T are tumorigenic
by: Katie L. Bailey, et al.
Published: (2021-06-01)

Sotorasib in KRASG12C mutated lung cancer: Can we rule out cracking KRAS led to worse overall survival?
by: Timothée Olivier, et al.
Published: (2023-02-01)

Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells
by: Mingtian Che, et al.
Published: (2020-06-01)