Mre11 assembles linear DNA fragments into DNA damage signaling complexes.
Mre11/Rad50/Nbs1 complex (MRN) is essential to suppress the generation of double-strand breaks (DSBs) during DNA replication. MRN also plays a role in the response to DSBs created by DNA damage. Hypomorphic mutations in Mre11 (which causes an ataxia-telangiectasia-like disease [ATLD]) and mutations...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2004-05-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC406388?pdf=render |