Mutation in the 26S proteasome regulatory subunit rpn2 gene in Plasmodium falciparum confers resistance to artemisinin

Mutation in the 26S proteasome regulatory subunit rpn2 gene in Plasmodium falciparum confers resistance to artemisinin

IntroductionMalaria parasites increasingly develop resistance to all drugs available in the market, hampering the goal of reducing malaria burden.MethodsHerein, we evaluated the impact of a single-nucleotide variant, E738K, present in the 26S proteasome regulatory subunit rpn2 gene, identified in Pl...

Full description

Bibliographic Details
Main Authors: Adriana F. Gonçalves, Ana Lima-Pinheiro, Miguel Teixeira, Gustavo Capatti Cassiano, Pedro Cravo, Pedro E. Ferreira
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
malaria
Plasmodium falciparum
drug resistance
proteasome
genetic engineering
artemisinin
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1342856/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2024.1342856/full

Similar Items