Memantine increases NMDA receptor level in the prefrontal cortex but fails to reverse apomorphine-induced conditioned place preference in rats

Studies have shown that inflammation and neurodegeneration may accompany the development of addiction to apomorphine and that the glutamate NMDA receptor antagonist, memantine, may be neuroprotective. The similarity between apomorphine and dopamine with regard to their chemical, pharmacological and...

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Bibliographic Details
Main Authors: Ziphozethu Ndlazi, Oualid Abboussi, Musa Mabandla, Willie Daniels
Format: Article
Language:English
Published: AIMS Press 2018-09-01
Series:AIMS Neuroscience
Subjects:
Online Access:http://www.aimspress.com/article/10.3934/Neuroscience.2018.4.211/fulltext.html