Non-apical membrane antigen 1 (AMA1) IgGs from Malian children interfere with functional activity of AMA1 IgGs as judged by growth inhibition assay.

Non-apical membrane antigen 1 (AMA1) IgGs from Malian children interfere with functional activity of AMA1 IgGs as judged by growth inhibition assay.

Apical membrane antigen 1 (AMA1) is one of the best-studied blood-stage malaria vaccine candidates. When an AMA1 vaccine was tested in a malaria naïve population, it induced functionally active antibodies judged by Growth Inhibition Assay (GIA). However, the same vaccine failed to induce higher grow...

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Bibliographic Details
Main Authors: Kazutoyo Miura, Suwani Perera, Sarah Brockley, Hong Zhou, Joan A Aebig, Samuel E Moretz, Louis H Miller, Ogobara K Doumbo, Issaka Sagara, Alassane Dicko, Ruth D Ellis, Carole A Long
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3113848?pdf=render

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http://europepmc.org/articles/PMC3113848?pdf=render

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