eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition

eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition

ABSTRACT RNA-activated protein kinase (PKR) is a major innate immune factor that senses viral double-stranded RNA (dsRNA) and phosphorylates eukaryotic initiation factor (eIF) 2α. Phosphorylation of the α subunit converts the eIF2αβγ complex into a stoichiometric inhibitor of eukaryotic initiation f...

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Bibliographic Details
Main Authors: Jennifer Deborah Wuerth, Matthias Habjan, Markus Kainulainen, Besim Berisha, Damien Bertheloot, Giulio Superti-Furga, Andreas Pichlmair, Friedemann Weber
Format: Article
Language:English
Published: American Society for Microbiology 2020-08-01
Series:mBio
Subjects:
PKR
phospho-eIF2α
translation inhibition
integrated stress response
viral PKR antagonist
eIF2B
Online Access:https://journals.asm.org/doi/10.1128/mBio.00976-20

Internet

https://journals.asm.org/doi/10.1128/mBio.00976-20

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