miR-155 exerts posttranscriptional control of autoimmune regulator (Aire) and tissue-restricted antigen genes in medullary thymic epithelial cells

miR-155 exerts posttranscriptional control of autoimmune regulator (Aire) and tissue-restricted antigen genes in medullary thymic epithelial cells

Abstract Background The autoimmune regulator (Aire) gene is critical for the appropriate establishment of central immune tolerance. As one of the main controllers of promiscuous gene expression in the thymus, Aire promotes the expression of thousands of downstream tissue-restricted antigen (TRA) gen...

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Bibliographic Details
Main Authors: Pedro Paranhos Tanaka, Ernna Hérida Oliveira, Mayara Cristina Vieira-Machado, Max Jordan Duarte, Amanda Freire Assis, Karina Fittipaldi Bombonato-Prado, Geraldo Aleixo Passos
Format: Article
Language:English
Published: BMC 2022-05-01
Series:BMC Genomics
Subjects:
Aire
Posttranscriptional control
miR-155
Medullary thymic epithelial cell
Transwell migration
Online Access:https://doi.org/10.1186/s12864-022-08631-4

Internet

https://doi.org/10.1186/s12864-022-08631-4

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