Pimarane Diterpenoids from the Seeds of <i>Caesalpinia minax</i> as PTP1B Inhibitors and Insulin Sensitizers

Pimarane Diterpenoids from the Seeds of <i>Caesalpinia minax</i> as PTP1B Inhibitors and Insulin Sensitizers

Protein-tyrosine phosphatase 1B (PTP1B) has been considered as a promising target for treating insulin resistance. In searching for naturally occurring PTB1B antagonists, two new pimarane diterpenoids, named 2α-hydroxy-7-oxo-pimara-8(9),15-diene (<b>1</b>) and 19-hydroxy-2α-acetoxy-7-oxo...

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Bibliographic Details
Main Authors: Yunshao Xu, Zheling Feng, Tian Zhang, Peng Lv, Jun Cao, Dan Li, Cheng Peng, Ligen Lin
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
pimarane diterpenoids
<i>Caesalpinia minax</i>
PTP1B
glucose uptake
C2C12 myotubes
Online Access:https://www.mdpi.com/1420-3049/25/20/4674

Internet

https://www.mdpi.com/1420-3049/25/20/4674

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