Population Pharmacokinetic Estimates Suggest Elevated Clearance and Distribution Volume of Desethylamodiaquine in Pediatric Patients with Sickle Cell Disease Treated with Artesunate-Amodiaquine

Population Pharmacokinetic Estimates Suggest Elevated Clearance and Distribution Volume of Desethylamodiaquine in Pediatric Patients with Sickle Cell Disease Treated with Artesunate-Amodiaquine

Background: There is limited information on the safety or efficacy of currently recommended antimalarial drugs in patients with sickle cell disease (SCD), a population predisposed to worse outcomes if affected by acute malaria. Artesunate-amodiaquine (ASAQ) is the first-line treatment for uncomplica...

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Main Authors: George O. Adjei, MD, PhD, Seth K. Amponsah, PhD, Bamenla Q. Goka, MB. ChB, MRCP, FWACP, Christabel Enweronu-Laryea, MBBS, MSc, FRCPCH, Lorna Renner, MB. ChB, MPH, FRCPCH, FGCPS, Abdul Malik Sulley, MSc, Michael Alifrangis, MSc, PhD, Jorgen A.L. Kurtzhals, MD, PhD
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Current Therapeutic Research
Online Access:http://www.sciencedirect.com/science/article/pii/S0011393X18300638

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http://www.sciencedirect.com/science/article/pii/S0011393X18300638

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