Inhibition of STAT3 by niclosamide synergizes with erlotinib against head and neck cancer.

Epidermal growth factor receptor (EGFR) is extensively expressed in head and neck cancer. However, EGFR-targeted therapy has only modest efficacy in head and neck cancer, through mechanisms that are not fully understood. Here, we found that inhibition of EGFR by erlotinib stimulated phosphorylation...

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Bibliographic Details
Main Authors: Rui Li, Shuo You, Zhongliang Hu, Zhuo G Chen, Gabriel L Sica, Fadlo R Khuri, Walter J Curran, Dong M Shin, Xingming Deng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3760825?pdf=render