Lymph Node Follicle‐Targeting STING Agonist Nanoshells Enable Single‐Shot M2e Vaccination for Broad and Durable Influenza Protection

Lymph Node Follicle‐Targeting STING Agonist Nanoshells Enable Single‐Shot M2e Vaccination for Broad and Durable Influenza Protection

Abstract The highly conserved matrix protein 2 ectodomain (M2e) of influenza viruses presents a compelling vaccine antigen candidate for stemming the pandemic threat of the mutation‐prone pathogen, yet the low immunogenicity of the diminutive M2e peptide renders vaccine development challenging. A hi...

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Bibliographic Details
Main Authors: Hsiao‐Han Tsai, Ping‐Han Huang, Leon CW Lin, Bing‐Yu Yao, Wan‐Ting Liao, Chen‐Hsueh Pai, Yu‐Han Liu, Hui‐Wen Chen, Che‐Ming J. Hu
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:Advanced Science
Subjects:
follicular dendritic cells
germinal center
lymph node follicle targeting
matrix protein 2 ectodomain antigen
nanoshell
stimulator of interferon genes agonist
Online Access:https://doi.org/10.1002/advs.202206521

Internet

https://doi.org/10.1002/advs.202206521

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