An internalizing antibody targeting of cell surface GRP94 effectively suppresses tumor angiogenesis of colorectal cancer

An internalizing antibody targeting of cell surface GRP94 effectively suppresses tumor angiogenesis of colorectal cancer

Colorectal cancer (CRC) is one of the life-threatening malignancies worldwide. Thus, novel potential therapeutic targets and therapeutics for the treatment of CRC need to be identified to improve the clinical outcomes of patients with CRC. In this study, we found that glucose-regulated protein 94 (G...

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Bibliographic Details
Main Authors: Yea Bin Cho, Ji Woong Kim, Kyun Heo, Hyun Jung Kim, Sumi Yun, Hye Seung Lee, Ha Gyeong Shin, Hyunbo Shim, Hanjin Yu, Yun-Hee Kim, Sukmook Lee
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Cell surface GRP94
Tumor angiogenesis
Fully human antibody
Internalization
Downregulation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222004401

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http://www.sciencedirect.com/science/article/pii/S0753332222004401

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