ZSWIM4 inhibition improves chemosensitivity in epithelial ovarian cancer cells by suppressing intracellular glycine biosynthesis

ZSWIM4 inhibition improves chemosensitivity in epithelial ovarian cancer cells by suppressing intracellular glycine biosynthesis

Abstract Background Zinc finger SWIM-type containing 4 (ZSWIM4) induces drug resistance in breast cancer cells. However, its role in epithelial ovarian cancer (EOC) remains unknown. In this study, we aimed to investigate the clinical significance of ZSWIM4 expression in EOC and develop new clinical...

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Bibliographic Details
Main Authors: Kunxiang Gong, Yinger Huang, Yanqin Zheng, Wenbo Hao, Kun Shi
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Translational Medicine
Subjects:
Epithelial ovarian cancer
Carboplatin
ZSWIM4
Chemosensitivity
FOXK1
Glycine biosynthesis
Online Access:https://doi.org/10.1186/s12967-024-04980-8

Internet

https://doi.org/10.1186/s12967-024-04980-8

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