On Characterizing the Interactions between Proteins and Guanine Quadruplex Structures of Nucleic Acids

Guanine quadruplexes (G4s) are four-stranded secondary structures of nucleic acids which are stabilized by noncanonical hydrogen bonding systems between the nitrogenous bases as well as extensive base stacking, or pi-pi, interactions. Formation of these structures in either genomic DNA or cellular R...

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Bibliographic Details
Main Authors: Ewan K. S. McRae, Evan P. Booy, Gay Pauline Padilla-Meier, Sean A. McKenna
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Journal of Nucleic Acids
Online Access:http://dx.doi.org/10.1155/2017/9675348