Single‐cell quantification of IL‐2 response by effector and regulatory T cells reveals critical plasticity in immune response

Single‐cell quantification of IL‐2 response by effector and regulatory T cells reveals critical plasticity in immune response

Understanding how the immune system decides between tolerance and activation by antigens requires addressing cytokine regulation as a highly dynamic process. We quantified the dynamics of interleukin‐2 (IL‐2) signaling in a population of T cells during an immune response by combining in silico model...

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Bibliographic Details
Main Authors: Ofer Feinerman, Garrit Jentsch, Karen E Tkach, Jesse W Coward, Matthew M Hathorn, Michael W Sneddon, Thierry Emonet, Kendall A Smith, Grégoire Altan‐Bonnet
Format: Article
Language:English
Published: Springer Nature 2010-01-01
Series:Molecular Systems Biology
Subjects:
cellular heterogeneity
computer modeling
IL‐2 signaling
immunology
regulatory T cells
Online Access:https://doi.org/10.1038/msb.2010.90

Internet

https://doi.org/10.1038/msb.2010.90

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