HIF-1α siRNA Leads to Apoptosis of Pancreatic Cancer Cells under Hypoxic Conditions

HIF-1α siRNA Leads to Apoptosis of Pancreatic Cancer Cells under Hypoxic Conditions

OBJECTIVE To explore the role of hypoxic inducible factor-1α (HIF-1 α ) in the proliferation and apoptosis of pancreatic cancer cells under hypoxic conditions. METHODS A cassette encoding small interference RNA (siRNA) targeting HIF-1 α mediated by recombinant adeno-associated virus (rAAV) was co...

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Bibliographic Details
Main Author: Chuangui CHEN, Jianqiu CHEN, Jinjin SUN
Format: Article
Language:English
Published: China Anti-Cancer Association 2009-02-01
Series:Cancer Biology & Medicine
Subjects:
recombinant adeno-associated virus (rAAV)
hypoxia inducible factor (HIF)
small interference RNA (siRNA)
proliferation
apoptosis.
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/167

Internet

http://www.cancerbiomed.org/index.php/cocr/article/view/167

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