Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians

Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians

In contrast to transcriptional regulation, the function of alternative splicing (AS) in stem cells is poorly understood. In mammals, MBNL proteins negatively regulate an exon program specific of embryonic stem cells; however, little is known about the in vivo significance of this regulation. We stud...

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Bibliographic Details
Main Authors: Jordi Solana, Manuel Irimia, Salah Ayoub, Marta Rodriguez Orejuela, Vera Zywitza, Marvin Jens, Javier Tapial, Debashish Ray, Quaid Morris, Timothy R Hughes, Benjamin J Blencowe, Nikolaus Rajewsky
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-08-01
Series:eLife
Subjects:
stem cells
Schmidtea mediterranea
alternative splicing
post-transcriptional gene regulation
regeneration
planaria
Online Access:https://elifesciences.org/articles/16797

Internet

https://elifesciences.org/articles/16797

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