Decreased Glycogenolysis by miR-338-3p Promotes Regional Glycogen Accumulation Within the Spinal Cord of Amyotrophic Lateral Sclerosis Mice

Decreased Glycogenolysis by miR-338-3p Promotes Regional Glycogen Accumulation Within the Spinal Cord of Amyotrophic Lateral Sclerosis Mice

Metabolic dysfunction is a hallmark of age-related neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). But the crosstalk between metabolic alteration and disease progression in ALS is still largely unknown. Glycogen, a branched polymer of glucose residues, is universally recog...

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Bibliographic Details
Main Authors: Chunyu Li, Qianqian Wei, Xiaojing Gu, Yongping Chen, Xueping Chen, Bei Cao, Ruwei Ou, Huifang Shang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
ALS
glycogen
glycogenolysis
PYGB
miR-338-3p
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00114/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00114/full

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