Preclinical Absorption, Distribution, Metabolism, and Excretion of Sodium Danshensu, One of the Main Water-Soluble Ingredients in Salvia miltiorrhiza, in Rats

Preclinical Absorption, Distribution, Metabolism, and Excretion of Sodium Danshensu, One of the Main Water-Soluble Ingredients in Salvia miltiorrhiza, in Rats

In this study, the absorption, distribution, metabolism and excretion (ADME) of sodium danshensu (Sodium DL-β-(3, 4-dihydroxyphenyl)lactate), one of the main water-soluble active constituents in Salvia miltiorrhiza, were evaluated in rats. Pharmacokinetic study was evaluated in doses of 15, 30, and...

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Bibliographic Details
Main Authors: Xiangguo Meng, Jingjing Jiang, Hui Pan, Shengyuan Wu, Shuowen Wang, Yuefen Lou, Guorong Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
sodium danshensu
pharmacokinetics
LC-MS/MS
ADME
bioavailability study
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00554/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00554/full

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