Synergistic association of resveratrol and histone deacetylase inhibitors as treatment in amyotrophic lateral sclerosis

Synergistic association of resveratrol and histone deacetylase inhibitors as treatment in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with motor neuron degeneration, progressive paralysis and finally death. Despite the research efforts, currently there is no cure for ALS. In recent years, multiple epigenetic mechanisms have been associated with neu...

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Bibliographic Details
Main Authors: Edoardo Parrella, Vanessa Porrini, Ilaria Scambi, Michele M. Gennari, Cristina Gussago, Oluwamolakun Bankole, Marina Benarese, Raffaella Mariotti, Marina Pizzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
amyotrophic lateral sclerosis (ALS)
NF-κB/RelA
histone acetylation
resveratrol
histone deacetylase (HDAC) inhibitors
epigenetic drugs
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1017364/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1017364/full

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