A Versatile and Efficient Novel Approach for Mendelian Randomization Analysis with Application to Assess the Causal Effect of Fetal Hemoglobin on Anemia in Sickle Cell Anemia

A Versatile and Efficient Novel Approach for Mendelian Randomization Analysis with Application to Assess the Causal Effect of Fetal Hemoglobin on Anemia in Sickle Cell Anemia

Mendelian randomization (MR) is increasingly employed as a technique to assess the causation of a risk factor on an outcome using observational data. The two-stage least-squares (2SLS) procedure is commonly used to examine the causation using genetic variants as the instrument variables. The validit...

Full description

Bibliographic Details
Main Authors: Janaka S. S. Liyanage, Jeremie H. Estepp, Kumar Srivastava, Sara R. Rashkin, Vivien A. Sheehan, Jane S. Hankins, Clifford M. Takemoto, Yun Li, Yuehua Cui, Motomi Mori, Stephen Burgess, Michael R. DeBaun, Guolian Kang
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Mathematics
Subjects:
Mendelian randomization
extreme phenotype sequencing
causal inference
genome-wide association studies
next generation sequencing studies
Online Access:https://www.mdpi.com/2227-7390/10/20/3743

Internet

https://www.mdpi.com/2227-7390/10/20/3743

Similar Items