Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells
The RIG-I-like receptors RIG-I, LGP2, and MDA5 initiate an antiviral response that includes production of type I interferons (IFNs). The nature of the RNAs that trigger MDA5 activation in infected cells remains unclear. Here, we purify and characterise LGP2/RNA complexes from cells infected with enc...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2014-02-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/01535 |