SMAC/Diablo controls proliferation of cancer cells by regulating phosphatidylethanolamine synthesis

SMAC/Diablo controls proliferation of cancer cells by regulating phosphatidylethanolamine synthesis

SMAC/Diablo, a pro‐apoptotic protein, yet it is overexpressed in several cancer types. We have described a noncanonical function for SMAC/Diablo as a regulator of lipid synthesis during cancer cell proliferation and development. Here, we explore the molecular mechanism through which SMAC/Diablo regu...

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Bibliographic Details
Main Authors: Swaroop Kumar Pandey, Avijit Paul, Anna Shteinfer‐Kuzmine, Ran Zalk, Uwe Bunz, Varda Shoshan‐Barmatz
Format: Article
Language:English
Published: Wiley 2021-11-01
Series:Molecular Oncology
Subjects:
cancer
mitochondria
phosphatidylethanolamine synthesis
phospholipids
PSD
SMAC/Diablo
Online Access:https://doi.org/10.1002/1878-0261.12959

Internet

https://doi.org/10.1002/1878-0261.12959

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