Ability of metformin to deplete NAD+ contributes to cancer cell susceptibility to metformin cytotoxicity and is dependent on NAMPT expression

Ability of metformin to deplete NAD+ contributes to cancer cell susceptibility to metformin cytotoxicity and is dependent on NAMPT expression

BackgroundNicotinamide adenine dinucleotide (NAD+) is vital for not only energy metabolism but also signaling pathways. A major source of NAD+ depletion is the activation of poly (ADP-ribose) polymerase (PARP) in response to DNA damage. We have previously demonstrated that metformin can cause both c...

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Bibliographic Details
Main Authors: Yongxian Zhuang, Allison B. Haugrud, Meg A. Schaefer, Shanta M. Messerli, W. Keith Miskimins
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Oncology
Subjects:
metformin
nicotinamide adenine dinucleotide (NAD+)
nicotinamide phosphoribosyltransferase (NAMPT)
tumorigenesis
breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1225220/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1225220/full

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