Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming

Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming

Abstract Background Chemotherapy (CT) is central to the treatment of triple negative breast cancer (TNBC), but drug toxicity and resistance place strong restrictions on treatment regimes. Fasting sensitizes cancer cells to a range of chemotherapeutic agents and also ameliorates CT-associated adverse...

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Bibliographic Details
Main Authors: Ioannis S. Pateras, Chloe Williams, Despoina D. Gianniou, Aggelos T. Margetis, Margaritis Avgeris, Pantelis Rousakis, Aigli-Ioanna Legaki, Peter Mirtschink, Wei Zhang, Konstantina Panoutsopoulou, Anastasios D. Delis, Stamatis N. Pagakis, Wei Tang, Stefan Ambs, Ulrika Warpman Berglund, Thomas Helleday, Anastasia Varvarigou, Antonios Chatzigeorgiou, Anders Nordström, Ourania E. Tsitsilonis, Ioannis P. Trougakos, Jonathan D. Gilthorpe, Teresa Frisan
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Translational Medicine
Subjects:
Breast cancer
Triple negative breast cancer
Caloric restriction
Fasting
Starvation
Oxidative stress
Online Access:https://doi.org/10.1186/s12967-023-03935-9

Internet

https://doi.org/10.1186/s12967-023-03935-9

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