HIF-PHD inhibitor regulates the function of group2 innate lymphoid cells and polarization of M2 macrophages

HIF-PHD inhibitor regulates the function of group2 innate lymphoid cells and polarization of M2 macrophages

Abstract Hypoxia-inducible factor-prolyl hydroxylase (HIF-PHD) inhibitors are therapeutic agents for renal anemia that work through HIF2-mediated upregulation of erythropoietin (EPO) and have also been reported to suppress renal fibrosis. Group 2 innate lymphoid cells (ILC2s) have been proven to be...

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Bibliographic Details
Main Authors: Ryuichi Nagashima, Hiroki Ishikawa, Yoshihiro Kuno, Chikara Kohda, Masayuki Iyoda
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-29161-3

Internet

https://doi.org/10.1038/s41598-023-29161-3

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