DNMT3A and DNMT3B Targeting as an Effective Radiosensitizing Strategy in Embryonal Rhabdomyosarcoma

DNMT3A and DNMT3B Targeting as an Effective Radiosensitizing Strategy in Embryonal Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood. Recently, we demonstrated the overexpression of both DNA methyltransferase 3A (DNMT3A) and 3B (DNMT3B) in RMS tumour biopsies and cell lines compared to normal skeletal muscle. Radiotherapy may often fail due to the abnormal...

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Bibliographic Details
Main Authors: Simona Camero, Giulia Vitali, Paola Pontecorvi, Simona Ceccarelli, Eleni Anastasiadou, Francesca Cicchetti, Elisabetta Flex, Silvia Pomella, Matteo Cassandri, Rossella Rota, Francesco Marampon, Cinzia Marchese, Amalia Schiavetti, Francesca Megiorni
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
rhabdomyosarcoma
DNMT3A
DNMT3B
radiotherapy
target therapies
RNA interference
Online Access:https://www.mdpi.com/2073-4409/10/11/2956

Internet

https://www.mdpi.com/2073-4409/10/11/2956

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