Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction

Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction

Abstract Background Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger. Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associa...

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Bibliographic Details
Main Authors: Songjiang Yin, Li Zhang, Liang Ding, Zhengquan Huang, Bo Xu, XiaoChen Li, Peimin Wang, Jun Mao
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Inflammation
Subjects:
Chondrocyte apoptosis
Osteoarthritis
Transient receptor potential ankyrin 1
Calcium overload
Mitochondrial dysfunction
Online Access:http://link.springer.com/article/10.1186/s12950-018-0204-9

Internet

http://link.springer.com/article/10.1186/s12950-018-0204-9

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