Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells Regulation
Mesenchymal stromal/stem cells (MSCs) are multipotent cells that can differentiate to various specialized cells, which have the potential capacity to differentiate properly and accelerate recovery in damaged sites of the body. This stem cell technology has become the fundamental element in regenerat...
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| Format: | Article |
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MDPI AG
2018-05-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/7/5/36 |
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| author | Satoru Matsuda Yukie Nakagawa Yasuko Kitagishi Atsuko Nakanishi Toshiyuki Murai |
| author_facet | Satoru Matsuda Yukie Nakagawa Yasuko Kitagishi Atsuko Nakanishi Toshiyuki Murai |
| author_sort | Satoru Matsuda |
| collection | DOAJ |
| description | Mesenchymal stromal/stem cells (MSCs) are multipotent cells that can differentiate to various specialized cells, which have the potential capacity to differentiate properly and accelerate recovery in damaged sites of the body. This stem cell technology has become the fundamental element in regenerative medicine. As reactive oxygen species (ROS) have been reported to adversely influence stem cell properties, it is imperative to attenuate the extent of ROS to the promising protective approach with MSCs’ regenerative therapy. Oxidative stress also affects the culture expansion and longevity of MSCs. Therefore, there is great need to identify a method to prevent oxidative stress and replicative senescence in MSCs. Phosphatase and tensin homologue deleted on chromosome 10/Protein kinase B, PKB (PTEN/AKT) and the tumor suppressor p53 pathway have been proven to play a pivotal role in regulating cell apoptosis by regulating the oxidative stress and/or ROS quenching. In this review, we summarize the current research and our view of how PTEN/AKT and p53 with their partners transduce signals downstream, and what the implications are for MSCs’ biology. |
| first_indexed | 2024-03-12T06:21:45Z |
| format | Article |
| id | doaj.art-664e4711235c4449ae95c3ef1943ae4e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:21:45Z |
| publishDate | 2018-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-664e4711235c4449ae95c3ef1943ae4e2023-09-03T02:12:11ZengMDPI AGCells2073-44092018-05-01753610.3390/cells7050036cells7050036Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells RegulationSatoru Matsuda0Yukie Nakagawa1Yasuko Kitagishi2Atsuko Nakanishi3Toshiyuki Murai4Department of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food and Nutrition, Faculty of Contemporary Human Life Science, Tezukayama University, Nara 631-8501, JapanDepartment of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanMesenchymal stromal/stem cells (MSCs) are multipotent cells that can differentiate to various specialized cells, which have the potential capacity to differentiate properly and accelerate recovery in damaged sites of the body. This stem cell technology has become the fundamental element in regenerative medicine. As reactive oxygen species (ROS) have been reported to adversely influence stem cell properties, it is imperative to attenuate the extent of ROS to the promising protective approach with MSCs’ regenerative therapy. Oxidative stress also affects the culture expansion and longevity of MSCs. Therefore, there is great need to identify a method to prevent oxidative stress and replicative senescence in MSCs. Phosphatase and tensin homologue deleted on chromosome 10/Protein kinase B, PKB (PTEN/AKT) and the tumor suppressor p53 pathway have been proven to play a pivotal role in regulating cell apoptosis by regulating the oxidative stress and/or ROS quenching. In this review, we summarize the current research and our view of how PTEN/AKT and p53 with their partners transduce signals downstream, and what the implications are for MSCs’ biology.http://www.mdpi.com/2073-4409/7/5/36p53PTENAKTMDM2superoxide dismutaseSODreactive oxygen speciesROSmesenchymal stromal/stem cellMSCstemness |
| spellingShingle | Satoru Matsuda Yukie Nakagawa Yasuko Kitagishi Atsuko Nakanishi Toshiyuki Murai Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells Regulation Cells p53 PTEN AKT MDM2 superoxide dismutase SOD reactive oxygen species ROS mesenchymal stromal/stem cell MSC stemness |
| title | Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells Regulation |
| title_full | Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells Regulation |
| title_fullStr | Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells Regulation |
| title_full_unstemmed | Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells Regulation |
| title_short | Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells Regulation |
| title_sort | reactive oxygen species superoxide dimutases and pten p53 akt mdm2 signaling loop network in mesenchymal stem stromal cells regulation |
| topic | p53 PTEN AKT MDM2 superoxide dismutase SOD reactive oxygen species ROS mesenchymal stromal/stem cell MSC stemness |
| url | http://www.mdpi.com/2073-4409/7/5/36 |
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