Inflammasome activation in peritumoral astrocytes is a key player in breast cancer brain metastasis development

Inflammasome activation in peritumoral astrocytes is a key player in breast cancer brain metastasis development

Abstract Inflammasomes, primarily responsible for the activation of IL-1β, have emerged as critical regulators of the tumor microenvironment. By using in vivo and in vitro brain metastasis models, as well as human samples to study the role of the NLRP3 inflammasome in triple-negative breast cancer (...

Full description

Bibliographic Details
Main Authors: Ádám Mészáros, Kinga Molnár, Csilla Fazakas, Bernát Nógrádi, Adél Lüvi, Tamás Dudás, László Tiszlavicz, Attila Elek Farkas, István Adorján Krizbai, Imola Wilhelm
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Acta Neuropathologica Communications
Subjects:
Brain metastasis
IL-1β
Inflammatory microenvironment
NLRP3 inflammasome
Peritumoral astrocytes
Triple-negative breast cancer
Online Access:https://doi.org/10.1186/s40478-023-01646-2

Internet

https://doi.org/10.1186/s40478-023-01646-2

Similar Items