Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases

Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases

Abstract The AAA+ ATPase valosin containing protein (VCP) is essential for cell and organ homeostasis, especially in cells of the nervous system. As part of a large network, VCP collaborates with many cofactors to ensure proteostasis under normal, stress, and disease conditions. A large number of mu...

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Bibliographic Details
Main Authors: Siwei Chu, Xinyi Xie, Carla Payan, Ursula Stochaj
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Molecular Neurodegeneration
Subjects:
Proteostasis
Neurodegeneration
Chaperone networks
Stress granules
Inclusion bodies
Valosin containing protein
Online Access:https://doi.org/10.1186/s13024-023-00639-y

Internet

https://doi.org/10.1186/s13024-023-00639-y

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