Impaired immune response and barrier function in GSPD-1-deficient C. elegans infected with Klebsiella pneumoniae

Impaired immune response and barrier function in GSPD-1-deficient C. elegans infected with Klebsiella pneumoniae

gspd-1-RNAi knockdown Caenorhabditis elegans was used as an immune-compromised model to investigate the role of G6PD in host-pathogen interactions. A shorted lifespan, increased bacterial burden and bacterial translocation were observed in gspd-1-knockdown C. elegans infected with Klebsiella pneumon...

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Bibliographic Details
Main Authors: Wan-Hua Yang, Po-Hsiang Chen, Hung-Hsin Chang, Hong Luen Kwok, Arnold Stern, Po-Chi Soo, Jiun-Han Chen, Hung-Chi Yang
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Current Research in Microbial Sciences
Subjects:
Klebsiella pneumoniae
Bacterial colonization
Tight junction
GSPD-1 C. elegans
Online Access:http://www.sciencedirect.com/science/article/pii/S2666517423000020

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http://www.sciencedirect.com/science/article/pii/S2666517423000020

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