Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice

Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice

Osteoporosis (OP) is a systemic skeletal disease that primarily affects the elderly population, which greatly increases the risk of fractures. Here we report that Kindlin-2 expression in adipose tissue increases during aging and high-fat diet fed and is accompanied by decreased bone mass. Kindlin-2...

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Bibliographic Details
Main Authors: Wanze Tang, Zhen Ding, Huanqing Gao, Qinnan Yan, Jingping Liu, Yingying Han, Xiaoting Hou, Zhengwei Liu, Litong Chen, Dazhi Yang, Guixing Ma, Huiling Cao
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Kindlin-2
Adipocyte
FAS
Bone homeostasis
AAV-Rec2-CasRx-sgK2
Osteoporosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523002514

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http://www.sciencedirect.com/science/article/pii/S2211383523002514

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