DNA methylation-based chromatin compartments and ChIP-seq profiles reveal transcriptional drivers of prostate carcinogenesis

DNA methylation-based chromatin compartments and ChIP-seq profiles reveal transcriptional drivers of prostate carcinogenesis

Abstract Background Profiles of DNA methylation of many tissues relevant in human disease have been obtained from microarrays and are publicly available. These can be used to generate maps of chromatin compartmentalization, demarcating open and closed chromatin across the genome. Additionally, large...

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Bibliographic Details
Main Authors: Poppy Simmonds, Erick Loomis, Edward Curry
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Genome Medicine
Subjects:
Prostate cancer
Epigenetics
Transcriptional regulation
Chromatin compartments
Online Access:http://link.springer.com/article/10.1186/s13073-017-0443-z

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http://link.springer.com/article/10.1186/s13073-017-0443-z

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